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The novel 2Fe–2S outer mitochondrial protein mitoNEET displays conformational flexibility in its N-terminal cytoplasmic tethering domain

A primary role for mitochondrial dysfunction is indicated in the pathogenesis of insulin resistance. A widely used drug for the treatment of type 2 diabetes is pioglitazone, a member of the thiazolidinedione class of molecules. MitoNEET, a 2Fe–2S outer mitochondrial membrane protein, binds pioglitaz...

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Autori principali: Conlan, Andrea R., Paddock, Mark L., Axelrod, Herbert L., Cohen, Aina E., Abresch, Edward C., Wiley, Sandra, Roy, Melinda, Nechushtai, Rachel, Jennings, Patricia A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Union of Crystallography 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705628/
https://ncbi.nlm.nih.gov/pubmed/19574633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309109019605
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