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Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis

Using Drosophila as a model system, we identified here a stringent requirement for Mre11-Rad50-Nbs (MRN) function in telomere protection during early embryonic development. Animals homozygous for hypomorphic mutations in either mre11 or nbs develop normally with minimal telomere dysfunction. However...

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Bibliografiske detaljer
Main Authors: Gao, Guanjun, Bi, Xiaolin, Chen, Jie, Srikanta, Deepa, Rong, Yikang S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705596/
https://ncbi.nlm.nih.gov/pubmed/19520832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902707106
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