Suppression of Alternative Lengthening of Telomeres by Sp100-Mediated Sequestration of the MRE11/RAD50/NBS1 Complex

Approximately 10% of cancers overall use alternative lengthening of telomeres (ALT) instead of telomerase to prevent telomere shortening, and ALT is especially common in astrocytomas and various types of sarcomas. The hallmarks of ALT in telomerase-negative cancer cells include a unique pattern of t...

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Détails bibliographiques
Auteurs principaux: Jiang, Wei-Qin, Zhong, Ze-Huai, Henson, Jeremy D., Neumann, Axel A., Chang, Andy C.-M., Reddel, Roger R.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2005
Sujets:
Chromosome Structure and Dynamics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1061646/
https://ncbi.nlm.nih.gov/pubmed/15767676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.7.2708-2721.2005
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