Suppression of Alternative Lengthening of Telomeres by Sp100-Mediated Sequestration of the MRE11/RAD50/NBS1 Complex

Approximately 10% of cancers overall use alternative lengthening of telomeres (ALT) instead of telomerase to prevent telomere shortening, and ALT is especially common in astrocytomas and various types of sarcomas. The hallmarks of ALT in telomerase-negative cancer cells include a unique pattern of t...

Full description

Saved in:
Bibliographic Details
Main Authors: Jiang, Wei-Qin, Zhong, Ze-Huai, Henson, Jeremy D., Neumann, Axel A., Chang, Andy C.-M., Reddel, Roger R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Chromosome Structure and Dynamics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1061646/
https://ncbi.nlm.nih.gov/pubmed/15767676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.7.2708-2721.2005
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items