Suppression of Alternative Lengthening of Telomeres by Sp100-Mediated Sequestration of the MRE11/RAD50/NBS1 Complex

Approximately 10% of cancers overall use alternative lengthening of telomeres (ALT) instead of telomerase to prevent telomere shortening, and ALT is especially common in astrocytomas and various types of sarcomas. The hallmarks of ALT in telomerase-negative cancer cells include a unique pattern of t...

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Главные авторы: Jiang, Wei-Qin, Zhong, Ze-Huai, Henson, Jeremy D., Neumann, Axel A., Chang, Andy C.-M., Reddel, Roger R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2005
Предметы:
Chromosome Structure and Dynamics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1061646/
https://ncbi.nlm.nih.gov/pubmed/15767676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.7.2708-2721.2005
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