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Osmolyte-induced separation of the mechanical folding phases of ubiquitin

Solvent molecules play key roles in the conformational dynamics of proteins. Here we use single molecule force-clamp spectroscopy to probe the role played by the stabilizing osmolyte glycerol on the conformational ensembles visited by a single ubiquitin protein folding after mechanical extension. Us...

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Bibliografski detalji
Glavni autori: Garcia-Manyes, Sergi, Dougan, Lorna, Fernández, Julio M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705578/
https://ncbi.nlm.nih.gov/pubmed/19541633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902090106
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