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Probing osmolyte participation in the unfolding transition state of a protein

Understanding the molecular mechanisms of osmolyte protection in protein stability has proved to be challenging. In particular, little is known about the role of osmolytes in the structure of the unfolding transition state of a protein, the main determinant of its dynamics. We have developed an expe...

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Detalhes bibliográficos
Main Authors: Dougan, Lorna, Genchev, Georgi Z., Lu, Hui, Fernandez, Julio M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116423/
https://ncbi.nlm.nih.gov/pubmed/21613570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101934108
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