Substrate shuttling between active sites of uroporphyrinogen decarboxylase is not required to generate coproporphyrinogen

Uroporphyrinogen Decarboxylase (URO-D; EC 4.1.1.37), the fifth enzyme of the heme biosynthetic pathway, is required for the production of heme, vitamin B12, siroheme, and chlorophyll precursors. URO-D catalyzes the sequential decarboxylation of the four acetate side chains on the pyrrole groups of u...

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Hlavní autoři: Phillips, John D., Warby, Christy A., Whitby, Frank G., Kushner, James P., Hill, Christopher P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705282/
https://ncbi.nlm.nih.gov/pubmed/19362562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.04.013
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