Endothelial Nitric Oxide Synthase Inhibits G(12/13) and Rho-Kinase Activated by the Angiotensin II Type-1 Receptor: Implication in Vascular Migration

BACKGROUND: Although, endothelial nitric oxide (NO) synthase (eNOS) is believed to antagonize vascular remodeling induced by the angiotensin II (AngII) type-1 receptor, the exact signaling mechanism remains unclear. METHODS AND RESULTS: By expressing eNOS to vascular smooth muscle cells (VSMCs) via...

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Autori principali: Suzuki, Hiroyuki, Kimura, Keita, Shirai, Heigoro, Eguchi, Kunie, Higuchi, Sadaharu, Hinoki, Akinari, Ishimaru, Kazuhiro, Brailoiu, Eugen, Dhanasekaran, Danny N., Stemmle, Laura N., Fields, Timothy A., Frank, Gerald D., Autieri, Michael V., Eguchi, Satoru
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704976/
https://ncbi.nlm.nih.gov/pubmed/19095998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.108.181024
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