α-Tocopheryl succinate and derivatives mediate the transcriptional repression of androgen receptor in prostate cancer cells by targeting the PP2A-JNK-Sp1-signaling axis

As part of our effort to understand the mechanism underlying α-tocopheryl succinate [vitamin E succinate (VES)]-mediated antitumor effects, we investigated the signaling pathway by which VES suppresses androgen receptor (AR) expression in prostate cancer cells. VES and, to a greater extent, its trun...

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Hlavní autoři: Huang, Po-Hsien, Wang, Dasheng, Chuang, Hsiao-Ching, Wei, Shuo, Kulp, Samuel K., Chen, Ching-Shih
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704284/
https://ncbi.nlm.nih.gov/pubmed/19420015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgp112
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