SIRT1 Histone Deacetylase Expression Is Associated with Microsatellite Instability and CpG Island Methylator Phenotype in Colorectal Cancer

The class III histone deacetylase SIRT1 plays an important role in epigenetic gene silencing. Inhibition of SIRT1 reactivates silenced genes, suggesting a possible therapeutic approach of targeted reversal of aberrantly silenced genes. In addition, SIRT1 may play a role in the well-known link betwee...

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Auteurs principaux: Nosho, Katsuhiko, Shima, Kaori, Irahara, Natsumi, Kure, Shoko, Firestein, Ron, Baba, Yoshifumi, Toyoda, Saori, Chen, Li, Hazra, Aditi, Giovannucci, Edward L., Fuchs, Charles S., Ogino, Shuji
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704253/
https://ncbi.nlm.nih.gov/pubmed/19430421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/modpathol.2009.49
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