Engineering GPCR signaling pathways with RASSLs

We are creating families of designer G-protein-coupled receptors (GPCRs) to allow for precise spatiotemporal control of GPCR signaling in vivo. These engineered GPCRs, called receptors activated solely by synthetic ligands (RASSLs), are unresponsive to endogenous ligands but can be activated by nano...

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Bibliografiska uppgifter
Huvudupphovsmän: Conklin, Bruce R., Hsiao, Edward C., Claeysen, Sylvie, Dumuis, Aline, Srinivasan, Supriya, Forsayeth, John R., Guettier, Jean-Marc, Chang, W.C., Pei, Ying, McCarthy, Ken D., Nissenson, Robert A., Wess, Jürgen, Bockaert, Joël, Roth, Bryan L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703467/
https://ncbi.nlm.nih.gov/pubmed/18668035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1232
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