Engineering GPCR signaling pathways with RASSLs

We are creating families of designer G-protein-coupled receptors (GPCRs) to allow for precise spatiotemporal control of GPCR signaling in vivo. These engineered GPCRs, called receptors activated solely by synthetic ligands (RASSLs), are unresponsive to endogenous ligands but can be activated by nano...

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Detalhes bibliográficos
Main Authors: Conklin, Bruce R., Hsiao, Edward C., Claeysen, Sylvie, Dumuis, Aline, Srinivasan, Supriya, Forsayeth, John R., Guettier, Jean-Marc, Chang, W.C., Pei, Ying, McCarthy, Ken D., Nissenson, Robert A., Wess, Jürgen, Bockaert, Joël, Roth, Bryan L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703467/
https://ncbi.nlm.nih.gov/pubmed/18668035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1232
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