Effects of 4-Vinylcyclohexene Diepoxide on Peripubertal and Adult Sprague–Dawley Rats: Ovarian, Clinical, and Pathologic Outcomes

Young rats treated daily with intraperitoneal 4-vinylcyclohexene diepoxide (VCD) undergo selective destruction of primordial follicles, resulting in gradual ovarian failure resembling the menopausal transition in women. To determine whether VCD has similar effects on ovaries of older rats, adult and...

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Autors principals: Muhammad, F Salih, Goode, Amanda K, Kock, Nancy D, Arifin, Esther A, Cline, J Mark, Adams, Michael R, Hoyer, Patricia B, Christian, Patricia J, Isom, Scott, Kaplan, Jay R, Appt, Susan E
Format: Artigo
Idioma:Inglês
Publicat: American Association for Laboratory Animal Science 2009
Matèries:
Rat Models
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703138/
https://ncbi.nlm.nih.gov/pubmed/19295054
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