Inhibition of Ovarian KIT Phosphorylation by the Ovotoxicant 4-Vinylcyclohexene Diepoxide in Rats

In vitro exposure of Postnatal Day 4 (PND4) rat ovaries to the occupational chemical 4-vinylcyclohexene diepoxide (VCD) destroys specifically primordial and primary follicles via acceleration of atresia. Because oocyte-expressed c-kit (KIT) plays a critical role in follicle survival and activation,...

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Autori principali: Mark-Kappeler, Connie J., Sen, Nivedita, Lukefahr, Ashley, McKee, Laurel, Sipes, I. Glenn, Konhilas, John, Hoyer, Patricia B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for the Study of Reproduction, Inc. 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184290/
https://ncbi.nlm.nih.gov/pubmed/21677306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.111.092742
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