Enhancement of the expression of HCV core gene does not enhance core-specific immune response in DNA immunization: advantages of the heterologous DNA prime, protein boost immunization regimen

BACKGROUND: Hepatitis C core protein is an attractive target for HCV vaccine aimed to exterminate HCV infected cells. However, although highly immunogenic in natural infection, core appears to have low immunogenicity in experimental settings. We aimed to design an HCV vaccine prototype based on core...

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Detalhes bibliográficos
Main Authors: Alekseeva, Ekaterina, Sominskaya, Irina, Skrastina, Dace, Egorova, Irina, Starodubova, Elizaveta, Kushners, Eriks, Mihailova, Marija, Petrakova, Natalia, Bruvere, Ruta, Kozlovskaya, Tatyana, Isaguliants, Maria, Pumpens, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702340/
https://ncbi.nlm.nih.gov/pubmed/19505299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-0556-7-7
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