The Immunogenicity in Mice of HCV Core Delivered as DNA Is Modulated by Its Capacity to Induce Oxidative Stress and Oxidative Stress Response

HCV core is an attractive HCV vaccine target, however, clinical or preclinical trials of core-based vaccines showed little success. We aimed to delineate what restricts its immunogenicity and improve immunogenic performance in mice. We designed plasmids encoding full-length HCV 1b core and its varia...

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Détails bibliographiques
Publié dans:Cells
Auteurs principaux: Jansons, Juris, Sominskaya, Irina, Petrakova, Natalia, Starodubova, Elizaveta S., Smirnova, Olga A., Alekseeva, Ekaterina, Bruvere, Ruta, Eliseeva, Olesja, Skrastina, Dace, Kashuba, Elena, Mihailova, Marija, Kochetkov, Sergey N., Ivanov, Alexander V., Isaguliants, Maria G.
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468923/
https://ncbi.nlm.nih.gov/pubmed/30823485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8030208
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