The Immunogenicity in Mice of HCV Core Delivered as DNA Is Modulated by Its Capacity to Induce Oxidative Stress and Oxidative Stress Response

HCV core is an attractive HCV vaccine target, however, clinical or preclinical trials of core-based vaccines showed little success. We aimed to delineate what restricts its immunogenicity and improve immunogenic performance in mice. We designed plasmids encoding full-length HCV 1b core and its varia...

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Publicado no:Cells
Principais autores: Jansons, Juris, Sominskaya, Irina, Petrakova, Natalia, Starodubova, Elizaveta S., Smirnova, Olga A., Alekseeva, Ekaterina, Bruvere, Ruta, Eliseeva, Olesja, Skrastina, Dace, Kashuba, Elena, Mihailova, Marija, Kochetkov, Sergey N., Ivanov, Alexander V., Isaguliants, Maria G.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468923/
https://ncbi.nlm.nih.gov/pubmed/30823485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8030208
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