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General and Versatile Autoinhibition of PLC Isozymes
Phospholipase C (PLC) isozymes are directly activated by heterotrimeric G proteins and Ras-like GTPases to hydrolyze phosphatidylinositol 4,5-bisphosphate into the second messengers diacylglycerol and inositol 1,4,5-trisphosphate. Although PLCs play central roles in myriad signaling cascades, the mo...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2702322/ https://ncbi.nlm.nih.gov/pubmed/18691970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.06.018 |
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