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The subendothelial extracellular matrix modulates JNK activation by flow

Atherosclerosis begins as local inflammation of artery walls at sites of disturbed flow. The c-Jun NH(2)-terminal kinase (JNK) is thought to be one of the major regulators of flow-dependent inflammatory gene expression in endothelial cells in atherosclerosis. We now show that JNK activation by both...

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Detalhes bibliográficos
Main Authors: Hahn, Cornelia, Orr, A. Wayne, Sanders, John M., Jhaveri, Krishna A., Schwartz, Martin Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702158/
https://ncbi.nlm.nih.gov/pubmed/19286608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.186486
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