A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug l-asparaginase

l-Asparaginase is a key therapeutic agent for treatment of childhood acute lymphoblastic leukemia (ALL). There is wide individual variation in pharmacokinetics, and little is known about its metabolism. The mechanisms of therapeutic failure with l-asparaginase remain speculative. Here, we now report...

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Главные авторы: Patel, Naina, Krishnan, Shekhar, Offman, Marc N., Krol, Marcin, Moss, Catherine X., Leighton, Carly, van Delft, Frederik W., Holland, Mark, Liu, JiZhong, Alexander, Seema, Dempsey, Clare, Ariffin, Hany, Essink, Monika, Eden, Tim O.B., Watts, Colin, Bates, Paul A., Saha, Vaskar
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2009
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701869/
https://ncbi.nlm.nih.gov/pubmed/19509471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37977
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