Recombinant L-Asparaginase from Zymomonas mobilis: A Potential New Antileukemic Agent Produced in Escherichia coli

L-asparaginase is an enzyme used as a chemotherapeutic agent, mainly for treating acute lymphoblastic leukemia. In this study, the gene of L-asparaginase from Zymomonas mobilis was cloned in pET vectors, fused to a histidine tag, and had its codons optimized. The L-asparaginase was expressed extrace...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Einsfeldt, Karen, Baptista, Isis Cavalcante, Pereira, Juliana Christina Castanheira Vicente, Costa-Amaral, Isabele Campos, da Costa, Elaine Sobral, Ribeiro, Maria Cecília Menks, Land, Marcelo Gerardin Poirot, Alves, Tito Lívio Moitinho, Larentis, Ariane Leites, Almeida, Rodrigo Volcan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890785/
https://ncbi.nlm.nih.gov/pubmed/27253887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156692
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