A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug l-asparaginase

l-Asparaginase is a key therapeutic agent for treatment of childhood acute lymphoblastic leukemia (ALL). There is wide individual variation in pharmacokinetics, and little is known about its metabolism. The mechanisms of therapeutic failure with l-asparaginase remain speculative. Here, we now report...

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Hlavní autoři: Patel, Naina, Krishnan, Shekhar, Offman, Marc N., Krol, Marcin, Moss, Catherine X., Leighton, Carly, van Delft, Frederik W., Holland, Mark, Liu, JiZhong, Alexander, Seema, Dempsey, Clare, Ariffin, Hany, Essink, Monika, Eden, Tim O.B., Watts, Colin, Bates, Paul A., Saha, Vaskar
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2009
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701869/
https://ncbi.nlm.nih.gov/pubmed/19509471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37977
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