A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug l-asparaginase

l-Asparaginase is a key therapeutic agent for treatment of childhood acute lymphoblastic leukemia (ALL). There is wide individual variation in pharmacokinetics, and little is known about its metabolism. The mechanisms of therapeutic failure with l-asparaginase remain speculative. Here, we now report...

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Bibliografiset tiedot
Päätekijät: Patel, Naina, Krishnan, Shekhar, Offman, Marc N., Krol, Marcin, Moss, Catherine X., Leighton, Carly, van Delft, Frederik W., Holland, Mark, Liu, JiZhong, Alexander, Seema, Dempsey, Clare, Ariffin, Hany, Essink, Monika, Eden, Tim O.B., Watts, Colin, Bates, Paul A., Saha, Vaskar
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2009
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701869/
https://ncbi.nlm.nih.gov/pubmed/19509471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37977
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