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A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug l-asparaginase
l-Asparaginase is a key therapeutic agent for treatment of childhood acute lymphoblastic leukemia (ALL). There is wide individual variation in pharmacokinetics, and little is known about its metabolism. The mechanisms of therapeutic failure with l-asparaginase remain speculative. Here, we now report...
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Main Authors: | , , , , , , , , , , , , , , , , |
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格式: | Artigo |
語言: | Inglês |
出版: |
American Society for Clinical Investigation
2009
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701869/ https://ncbi.nlm.nih.gov/pubmed/19509471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37977 |
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