Asparaginase combined with discontinuous dexamethasone improves antileukemic efficacy without increasing osteonecrosis in preclinical models

INTRODUCTION: Combination therapy for acute lymphoblastic leukemia (ALL) is highly effective but results in significant toxicity including osteonecrosis. Asparaginase is known to potentiate both the antileukemic and osteonecrosis-inducing effects of dexamethasone. The schedule of dexamethasone alter...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Karol, Seth E., Janke, Laura J., Panetta, John C., Ramsey, Laura B., Cai, Xiangjun, Payton, Monique A., Jenkins, David A., Evans, William E., Relling, Mary V.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502315/
https://ncbi.nlm.nih.gov/pubmed/31059548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216328
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