A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug l-asparaginase

l-Asparaginase is a key therapeutic agent for treatment of childhood acute lymphoblastic leukemia (ALL). There is wide individual variation in pharmacokinetics, and little is known about its metabolism. The mechanisms of therapeutic failure with l-asparaginase remain speculative. Here, we now report...

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Autori principali: Patel, Naina, Krishnan, Shekhar, Offman, Marc N., Krol, Marcin, Moss, Catherine X., Leighton, Carly, van Delft, Frederik W., Holland, Mark, Liu, JiZhong, Alexander, Seema, Dempsey, Clare, Ariffin, Hany, Essink, Monika, Eden, Tim O.B., Watts, Colin, Bates, Paul A., Saha, Vaskar
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701869/
https://ncbi.nlm.nih.gov/pubmed/19509471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37977
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