A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug l-asparaginase

l-Asparaginase is a key therapeutic agent for treatment of childhood acute lymphoblastic leukemia (ALL). There is wide individual variation in pharmacokinetics, and little is known about its metabolism. The mechanisms of therapeutic failure with l-asparaginase remain speculative. Here, we now report...

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Détails bibliographiques
Auteurs principaux: Patel, Naina, Krishnan, Shekhar, Offman, Marc N., Krol, Marcin, Moss, Catherine X., Leighton, Carly, van Delft, Frederik W., Holland, Mark, Liu, JiZhong, Alexander, Seema, Dempsey, Clare, Ariffin, Hany, Essink, Monika, Eden, Tim O.B., Watts, Colin, Bates, Paul A., Saha, Vaskar
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2009
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701869/
https://ncbi.nlm.nih.gov/pubmed/19509471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37977
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