Surface Plasmon Resonance Analysis of Antifungal Azoles Binding to CYP3A4 with Kinetic Resolution of Multiple Binding Orientations

The heme-containing Cytochrome P450s (CYPs) are a major enzymatic determinant of drug clearance and drug-drug interactions. The CYP3A4 isoform is inhibited by antifungal imidazoles or triazoles, which form low spin heme iron complexes via formation of a nitrogen-ferric iron coordinate bond. However,...

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Main Authors: Pearson, Josh T., Hill, John J., Swank, Jennifer, Isoherranen, Nina, Kunze, Kent L., Atkins, William M.
格式: Artigo
語言:Inglês
出版: 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701698/
https://ncbi.nlm.nih.gov/pubmed/16700545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0600042
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