Role of DNA damage-induced replication checkpoint in promoting lesion bypass by translesion synthesis in yeast

Unrepaired DNA lesions in the template strand block the replication fork. In yeast, Mec1 protein kinase-mediated replication checkpoint prevents the breakdown of replication forks and maintains viability in DNA-damaged cells going through the S phase. By ensuring that the replisome does not dissocia...

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Main Authors: Pagès, Vincent, Santa Maria, Sergio R., Prakash, Louise, Prakash, Satya
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2009
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701570/
https://ncbi.nlm.nih.gov/pubmed/19528320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1793409
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