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Retinoic Acid Promotes Limb Induction through Effects on Body Axis Extension but is Unnecessary for Limb Patterning
Retinoic acid (RA) is thought to be a key signaling molecule involved in limb bud patterning along the proximodistal or anteroposterior axes functioning through induction of Meis2 and Shh, respectively [1]. Here, we utilize Raldh2(-/-) and Raldh3(-/-) mouse embryos lacking RA synthesis [2] to demons...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701469/ https://ncbi.nlm.nih.gov/pubmed/19464179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2009.04.059 |
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