Retinoic Acid Promotes Limb Induction through Effects on Body Axis Extension but is Unnecessary for Limb Patterning

Retinoic acid (RA) is thought to be a key signaling molecule involved in limb bud patterning along the proximodistal or anteroposterior axes functioning through induction of Meis2 and Shh, respectively [1]. Here, we utilize Raldh2(-/-) and Raldh3(-/-) mouse embryos lacking RA synthesis [2] to demons...

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Main Authors: Zhao, Xianling, Sirbu, Ioan Ovidiu, Mic, Felix A., Molotkova, Natalia, Molotkov, Andrei, Kumar, Sandeep, Duester, Gregg
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701469/
https://ncbi.nlm.nih.gov/pubmed/19464179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2009.04.059
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