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Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis

Two isomers of retinoic acid (RA) may be necessary as ligands for retinoid signaling: all-trans-RA for RA receptors (RARs) and 9-cis-RA for retinoid X receptors (RXRs). This was explored by using retinaldehyde dehydrogenase (Raldh)2(-/-) mouse embryos lacking mesodermal RA synthesis that display ear...

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Detalhes bibliográficos
Main Authors: Mic, Felix A., Molotkov, Andrei, Benbrook, Doris M., Duester, Gregg
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC165842/
https://ncbi.nlm.nih.gov/pubmed/12782789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1231422100
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