Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis

Two isomers of retinoic acid (RA) may be necessary as ligands for retinoid signaling: all-trans-RA for RA receptors (RARs) and 9-cis-RA for retinoid X receptors (RXRs). This was explored by using retinaldehyde dehydrogenase (Raldh)2(-/-) mouse embryos lacking mesodermal RA synthesis that display ear...

Täydet tiedot

Bibliografiset tiedot

Julkaisussa:	Proc Natl Acad Sci U S A
Päätekijät:	Mic, Felix A., Molotkov, Andrei, Benbrook, Doris M., Duester, Gregg
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	National Academy of Sciences 2003
Aiheet:	Biological Sciences
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165842/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12782789/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1231422100
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