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Functional features cause misfolding of the ALS-provoking enzyme SOD1
The structural integrity of the ubiquitous enzyme superoxide dismutase (SOD1) relies critically on the correct coordination of Cu and Zn. Loss of these cofactors not only promotes SOD1 aggregation in vitro but also seems to be a key prerequisite for pathogenic misfolding in the neurodegenerative dis...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701049/ https://ncbi.nlm.nih.gov/pubmed/19497878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812046106 |
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