Functional features cause misfolding of the ALS-provoking enzyme SOD1

The structural integrity of the ubiquitous enzyme superoxide dismutase (SOD1) relies critically on the correct coordination of Cu and Zn. Loss of these cofactors not only promotes SOD1 aggregation in vitro but also seems to be a key prerequisite for pathogenic misfolding in the neurodegenerative dis...

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Detalhes bibliográficos
Main Authors: Nordlund, Anna, Leinartaitė, Lina, Saraboji, Kadhirvel, Aisenbrey, Christopher, Gröbner, Gerhard, Zetterström, Per, Danielsson, Jens, Logan, Derek T., Oliveberg, Mikael
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701049/
https://ncbi.nlm.nih.gov/pubmed/19497878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812046106
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