Functional features cause misfolding of the ALS-provoking enzyme SOD1

The structural integrity of the ubiquitous enzyme superoxide dismutase (SOD1) relies critically on the correct coordination of Cu and Zn. Loss of these cofactors not only promotes SOD1 aggregation in vitro but also seems to be a key prerequisite for pathogenic misfolding in the neurodegenerative dis...

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Autors principals: Nordlund, Anna, Leinartaitė, Lina, Saraboji, Kadhirvel, Aisenbrey, Christopher, Gröbner, Gerhard, Zetterström, Per, Danielsson, Jens, Logan, Derek T., Oliveberg, Mikael
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701049/
https://ncbi.nlm.nih.gov/pubmed/19497878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812046106
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