TNF and IL-1 Decrease RXRα, PPARα, PPARγ, LXRα, and the Coactivators SRC-1, PGC-1α, and PGC-1β in Liver Cells

During the acute phase response (APR), cytokines induce marked alterations in lipid metabolism including an increase in serum triglycerides, a decrease in hepatic fatty acid oxidation, a decrease in bile acid synthesis, and a decrease in HDL. Here we demonstrate that TNF and IL-1, but not IL-6, decr...

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Autores principales: Sun Kim, Min, Sweeney, Trevor R., Shigenaga, Judy K., Chui, Lisa G., Moser, Arthur, Grunfeld, Carl, Feingold, Kenneth R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700944/
https://ncbi.nlm.nih.gov/pubmed/17224343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2006.10.007
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