Growth retardation and altered autonomic control in mice lacking brain serotonin

Serotonin synthesis in mammals is initiated by 2 distinct tryptophan hydroxylases (TPH), TPH1 and TPH2. By genetically ablating TPH2, we created mice (Tph2(−/−)) that lack serotonin in the central nervous system. Surprisingly, these mice can be born and survive until adulthood. However, depletion of...

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Hauptverfasser: Alenina, Natalia, Kikic, Dana, Todiras, Mihail, Mosienko, Valentina, Qadri, Fatimunnisa, Plehm, Ralph, Boyé, Philipp, Vilianovitch, Larissa, Sohr, Reinhard, Tenner, Katja, Hörtnagl, Heide, Bader, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2009
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700938/
https://ncbi.nlm.nih.gov/pubmed/19520831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810793106
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