Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response

Physical exercise induces cell proliferation in the adult hippocampus in rodents. Serotonin (5-HT) and angiotensin (Ang) II are important mediators of the pro-mitotic effect of physical activity. Here, we examine precursor cells in the adult brain of mice lacking angiotensin-converting enzyme (ACE)...

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Publicat a:Cell Mol Life Sci
Autors principals: Klempin, Friederike, Mosienko, Valentina, Matthes, Susann, Villela, Daniel C., Todiras, Mihail, Penninger, Josef M., Bader, Michael, Santos, Robson A. S., Alenina, Natalia
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2018
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7079801/
https://ncbi.nlm.nih.gov/pubmed/29679094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-018-2815-y
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