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Growth retardation and altered autonomic control in mice lacking brain serotonin
Serotonin synthesis in mammals is initiated by 2 distinct tryptophan hydroxylases (TPH), TPH1 and TPH2. By genetically ablating TPH2, we created mice (Tph2(−/−)) that lack serotonin in the central nervous system. Surprisingly, these mice can be born and survive until adulthood. However, depletion of...
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| Main Authors: | , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2700938/ https://ncbi.nlm.nih.gov/pubmed/19520831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810793106 |
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