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Structure-activity relationship studies on anti-HCV activity of ring-expanded (‘fat’) nucleobase analogues containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system

In continuation of our structure-activity relationship studies on anti-HCV activity of the title imidazo[4,5-e][1,3]diazepine ring system, we report here the synthesis and effect on biological activity of introducing hydrophobic substituents at the 2-position of the heterocycle. Our results suggest...

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Bibliografiske detaljer
Main Authors: Zhang, Peng, Zhang, Ning, Korba, Brent E., Hosmane, Ramachandra S.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700783/
https://ncbi.nlm.nih.gov/pubmed/17300935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.01.085
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