A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen

BACKGROUND: Regulators of G protein signaling (RGSs) accelerate GTP hydrolysis by Gα subunits and profoundly inhibit signaling by G protein-coupled receptors (GPCRs). The distinct expression patterns and pathophysiologic regulation of RGS proteins suggest that inhibitors may have therapeutic potenti...

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Detaylı Bibliyografya
Asıl Yazarlar: Roof, Rebecca A, Roman, David L, Clements, Samuel T, Sobczyk-Kojiro, Katarzyna, Blazer, Levi L, Ota, Shodai, Mosberg, Henry I, Neubig, Richard R
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2009
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700083/
https://ncbi.nlm.nih.gov/pubmed/19463173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2210-9-9
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