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Expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor infiltrating T regulatory cells

TNFR2 is predominantly expressed by a subset of human and mouse CD4+CD25+FoxP3+ Tregs. In this study, we characterized the phenotype and function of TNFR2(+) Tregs in peripheral lymphoid tissues of normal and tumor bearing C57BL/6 mice. We found that TNFR2 was expressed on 30%−40% of peripheral acti...

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Autori principali: Chen, Xin, Subleski, Jeffrey J., Kopf, Heather, Howard, O.M.Zack, Männel, Daniela N., Oppenheim, Joost J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699949/
https://ncbi.nlm.nih.gov/pubmed/18453563
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