Mrc1 and DNA polymerase ε function together in linking DNA replication and the S phase checkpoint

Yeast Mrc1, ortholog of metazoan Claspin, is both a central component of normal DNA replication forks and a mediator of the S phase checkpoint. We report that Mrc1 interacts with Pol2, the catalytic subunit of DNA polymerase ε, essential for leading strand DNA replication and for the checkpoint. In...

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Detalhes bibliográficos
Main Authors: Lou, Huiqiang, Komata, Makiko, Katou, Yuki, Guan, Zhiyun, Reis, Clara C., Budd, Martin, Shirahige, Katsuhiko, Campbell, Judith L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699584/
https://ncbi.nlm.nih.gov/pubmed/18851837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.08.020
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