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Mrc1 and DNA polymerase ε function together in linking DNA replication and the S phase checkpoint
Yeast Mrc1, ortholog of metazoan Claspin, is both a central component of normal DNA replication forks and a mediator of the S phase checkpoint. We report that Mrc1 interacts with Pol2, the catalytic subunit of DNA polymerase ε, essential for leading strand DNA replication and for the checkpoint. In...
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| Asıl Yazarlar: | , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2008
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699584/ https://ncbi.nlm.nih.gov/pubmed/18851837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.08.020 |
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