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Follicular helper T cells are required for systemic autoimmunity
Production of high-affinity pathogenic autoantibodies appears to be central to the pathogenesis of lupus. Because normal high-affinity antibodies arise from germinal centers (GCs), aberrant selection of GC B cells, caused by either failure of negative selection or enhanced positive selection by foll...
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| Autores principales: | , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Rockefeller University Press
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699132/ https://ncbi.nlm.nih.gov/pubmed/19221396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081886 |
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