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Fluorescence changes reveal kinetic steps of muscarinic receptor–mediated modulation of phosphoinositides and Kv7.2/7.3 K(+) channels
G protein–coupled receptors initiate signaling cascades. M(1) muscarinic receptor (M(1)R) activation couples through Gα(q) to stimulate phospholipase C (PLC), which cleaves phosphatidylinositol 4,5-bisphosphate (PIP(2)). Depletion of PIP(2) closes PIP(2)-requiring Kv7.2/7.3 potassium channels (M cur...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699104/ https://ncbi.nlm.nih.gov/pubmed/19332618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200810075 |
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