T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation

After homing to lymph nodes, CD8(+) T cells are primed by dendritic cells (DCs) in three phases. During phase one, T cells undergo brief serial contacts with DCs for several hours, whereas phase two is characterized by stable T cell–DC interactions. We show here that the duration of phase one and T...

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Hauptverfasser: Henrickson, Sarah E, Mempel, Thorsten R, Mazo, Irina B, Liu, Bai, Artyomov, Maxim N, Zheng, Huan, Peixoto, Antonio, Flynn, Michael P, Senman, Balimkiz, Junt, Tobias, Wong, Hing C, Chakraborty, Arup K, von Andrian, Ulrich H
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698867/
https://ncbi.nlm.nih.gov/pubmed/18204450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni1559
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