LKB1 expressed in dendritic cells governs the development and expansion of thymus-derived regulatory T cells

Liver Kinase B1 (LKB1) plays a key role in cellular metabolism by controlling AMPK activation. However, its function in dendritic cell (DC) biology has not been addressed. Here, we find that LKB1 functions as a critical brake on DC immunogenicity, and when lost, leads to reduced mitochondrial fitnes...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Pelgrom, Leonard R., Patente, Thiago A., Sergushichev, Alexey, Esaulova, Ekaterina, Otto, Frank, Ozir-Fazalalikhan, Arifa, van der Zande, Hendrik J. P., van der Ham, Alwin J., van der Stel, Stefan, Artyomov, Maxim N., Everts, Bart
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796856/
https://ncbi.nlm.nih.gov/pubmed/30940876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-019-0161-8
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