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Spectroscopy and Kinetics of Wild-Type and Mutant Tyrosine Hydroxylase: Mechanistic Insight into O(2) Activation
Tyrosine Hydroxylase (TH) is a pterin-dependent non-heme iron enzyme that catalyzes the hydroxylation of L-tyr to L-DOPA in the rate-limiting step of catecholamine neurotransmitter biosynthesis. We have previously shown that the Fe(II) site in Phenylalanine Hydroxylase (PAH) converts from 6C to 5C o...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2698713/ https://ncbi.nlm.nih.gov/pubmed/19489646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja810080c |
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