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Reduction and Oxidation of the Active Site Iron in Tyrosine Hydroxylase: Kinetics and Specificity

Tyrosine hydroxylase (TyrH) is a pterin-dependent enzyme that catalyzes the hydroxylation of tyrosine to form dihydroxyphenylalanine. The oxidation state of the active site iron atom plays a central role in the regulation of the enzyme. The kinetics of reduction of ferric TyrH by several reductants...

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Detalhes bibliográficos
Main Authors: Frantom, Patrick A., Seravalli, Javier, Ragsdale, Stephen W., Fitzpatrick, Paul F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1945184/
https://ncbi.nlm.nih.gov/pubmed/16475826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi052283j
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