Human Immunodeficiency Virus Type 1 Nef Protein Targets CD4 to the Multivesicular Body Pathway

The Nef protein of human immunodeficiency virus type 1 downregulates the CD4 coreceptor from the surface of host cells by accelerating the rate of CD4 endocytosis through a clathrin/AP-2 pathway. Herein, we report that Nef has the additional function of targeting CD4 to the multivesicular body (MVB)...

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Detalhes bibliográficos
Main Authors: daSilva, Luis L. P., Sougrat, Rachid, Burgos, Patricia V., Janvier, Katy, Mattera, Rafael, Bonifacino, Juan S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698520/
https://ncbi.nlm.nih.gov/pubmed/19403684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00548-09
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