Mutation of a Conserved Residue (D123) Required for Oligomerization of Human Immunodeficiency Virus Type 1 Nef Protein Abolishes Interaction with Human Thioesterase and Results in Impairment of Nef Biological Functions

Nef is a myristoylated protein of 27 to 35 kDa that is conserved in primate lentiviruses. In vivo, Nef is required for high viral load and full pathological effects. In vitro, Nef has at least four activities: induction of CD4 and major histocompatibility complex (MHC) class I downregulation, enhanc...

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Detalhes bibliográficos
Main Authors: Liu, Lang Xia, Heveker, Nikolaus, Fackler, Oliver T., Arold, Stefan, Le Gall, Sylvie, Janvier, Katy, Peterlin, B. Matija, Dumas, Christian, Schwartz, Olivier, Benichou, Serge, Benarous, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC110886/
https://ncbi.nlm.nih.gov/pubmed/10799608
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