Mutation of a Conserved Residue (D123) Required for Oligomerization of Human Immunodeficiency Virus Type 1 Nef Protein Abolishes Interaction with Human Thioesterase and Results in Impairment of Nef Biological Functions

Nef is a myristoylated protein of 27 to 35 kDa that is conserved in primate lentiviruses. In vivo, Nef is required for high viral load and full pathological effects. In vitro, Nef has at least four activities: induction of CD4 and major histocompatibility complex (MHC) class I downregulation, enhanc...

Full description

Saved in:
Bibliographic Details
Main Authors: Liu, Lang Xia, Heveker, Nikolaus, Fackler, Oliver T., Arold, Stefan, Le Gall, Sylvie, Janvier, Katy, Peterlin, B. Matija, Dumas, Christian, Schwartz, Olivier, Benichou, Serge, Benarous, Richard
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC110886/
https://ncbi.nlm.nih.gov/pubmed/10799608
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items