Mutation of a Conserved Residue (D123) Required for Oligomerization of Human Immunodeficiency Virus Type 1 Nef Protein Abolishes Interaction with Human Thioesterase and Results in Impairment of Nef Biological Functions

Nef is a myristoylated protein of 27 to 35 kDa that is conserved in primate lentiviruses. In vivo, Nef is required for high viral load and full pathological effects. In vitro, Nef has at least four activities: induction of CD4 and major histocompatibility complex (MHC) class I downregulation, enhanc...

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Библиографические подробности
Главные авторы: Liu, Lang Xia, Heveker, Nikolaus, Fackler, Oliver T., Arold, Stefan, Le Gall, Sylvie, Janvier, Katy, Peterlin, B. Matija, Dumas, Christian, Schwartz, Olivier, Benichou, Serge, Benarous, Richard
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2000
Предметы:
Virus-Cell Interactions
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC110886/
https://ncbi.nlm.nih.gov/pubmed/10799608
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